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P09936

UniProt ID :

P09936

NCBI Taxonomy :

9606

Protein names :

Ubiquitin carboxyl-terminal hydrolase isozyme L1

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Endoplasmic reticulum membrane;

Length :

223

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0030424	Cellular Component	axon	IEA
GO:0005737	Cellular Component	cytoplasm	ISS
GO:0005829	Cellular Component	cytosol	IEA
GO:0005789	Cellular Component	endoplasmic reticulum membrane	IEA
GO:0043025	Cellular Component	neuronal cell body	IEA
GO:0005634	Cellular Component	nucleus	IDA
GO:0004197	Molecullar Function	cysteine-type endopeptidase activity	IDA
GO:0016874	Molecullar Function	ligase activity	IEA
GO:0008242	Molecullar Function	omega peptidase activity	IDA
GO:0043130	Molecullar Function	ubiquitin binding	IDA
GO:0004221	Molecullar Function	ubiquitin thiolesterase activity	TAS
GO:0007628	Biological Process	adult walking behavior	IEA
GO:0007412	Biological Process	axon target recognition	IEA
GO:0019896	Biological Process	axon transport of mitochondrion	IEA
GO:0008219	Biological Process	cell death	IEA
GO:0008283	Biological Process	cell proliferation	IEA
GO:0042755	Biological Process	eating behavior	IEA
GO:0048747	Biological Process	muscle fiber development	IEA
GO:0043407	Biological Process	negative regulation of MAP kinase activity	IDA
GO:0050905	Biological Process	neuromuscular process	IEA
GO:0016579	Biological Process	protein deubiquitination	IDA
GO:0006950	Biological Process	response to stress	IEA
GO:0019233	Biological Process	sensory perception of pain	IEA
GO:0006511	Biological Process	ubiquitin-dependent protein catabolic process	IEA

Catalytic activity :

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).PubMed:9774100 reports the association of mutati

SWISS-MODEL Repository :

P09936

Sequences :

MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

Function :

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.