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P08294

UniProt ID :

P08294

NCBI Taxonomy :

9606

Protein names :

Extracellular superoxide dismutase [Cu-Zn]

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

240

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	IBA
GO:0031012	Cellular Component	extracellular matrix	IEA
GO:0005615	Cellular Component	extracellular space	IDA
GO:0005739	Cellular Component	mitochondrion	IBA
GO:0005634	Cellular Component	nucleus	IBA
GO:0005802	Cellular Component	trans-Golgi network	IEA
GO:0005507	Molecullar Function	copper ion binding	IBA
GO:0008201	Molecullar Function	heparin binding	IEA
GO:0004784	Molecullar Function	superoxide dismutase activity	IBA
GO:0008270	Molecullar Function	zinc ion binding	IBA
GO:0019430	Biological Process	removal of superoxide radicals	IBA
GO:0046688	Biological Process	response to copper ion	IEA
GO:0001666	Biological Process	response to hypoxia	IEA

Catalytic activity :

2 superoxide + 2 H⁺ = O₂ + H₂O₂.

SWISS-MODEL Repository :

P08294

Sequences :

MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLWERQAREHSERKKRRRESECKAA

Function :

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.