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P07314

UniProt ID :

P07314

NCBI Taxonomy :

10116

Protein names :

Gamma-glutamyltranspeptidase 1

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Membrane;

Length :

568

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005615	Cellular Component	extracellular space	IDA
GO:0005887	Cellular Component	integral to plasma membrane	TAS
GO:0003840	Molecullar Function	gamma-glutamyltransferase activity	IDA
GO:0036374	Molecullar Function	glutathione hydrolase activity	IEA
GO:0007568	Biological Process	aging	IEP
GO:0034599	Biological Process	cellular response to oxidative stress	IEP
GO:0006750	Biological Process	glutathione biosynthetic process	IEA
GO:0031179	Biological Process	peptide modification	IDA
GO:0032355	Biological Process	response to estradiol stimulus	IEP
GO:0032496	Biological Process	response to lipopolysaccharide	IEP
GO:0034612	Biological Process	response to tumor necrosis factor	IEP

Catalytic activity :

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.Glutathione + H₂O = L-cysteinylglycine + L-glutamate.Leukotriene C(4) + H₂O = leukotriene D(4) + L-glutamate.

Sequences :

MKNRFLVLGLVAVVLVFVIIGLCIWLPTTSGKPDHVYSRAAVATDAKRCSEIGRDMLQEGGSVVDAAIASLLCMGLINAHSMGIGGGLFFTIYNSTTRKAEVINAREMAPRLANTSMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLARALDKKRDIIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGARAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAEVIEHPMSIGLGDSTLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPTAYYEPEFYLPDDGGTAHLSVVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFTNQFGVAPSPANFIKPGKQPLSSMCPSIIVDKDGKVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKNIDQVVTAGLKTRHHHTEVTPDFIAVVQAVVRTSGGWAAASDSRKGGEPAGY

Function :

Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate.