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P06866

UniProt ID :

P06866

NCBI Taxonomy :

10116

Protein names :

Haptoglobin

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

347

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005783	Cellular Component	endoplasmic reticulum	IDA
GO:0005615	Cellular Component	extracellular space	IDA
GO:0005794	Cellular Component	Golgi apparatus	IDA
GO:0016209	Molecullar Function	antioxidant activity	IEA
GO:0003824	Molecullar Function	catalytic activity	IEA
GO:0030492	Molecullar Function	hemoglobin binding	IDA
GO:0042803	Molecullar Function	protein homodimerization activity	IDA
GO:0002526	Biological Process	acute inflammatory response	IEP
GO:0006953	Biological Process	acute-phase response	IEA
GO:0042742	Biological Process	defense response to bacterium	IEA
GO:0001889	Biological Process	liver development	IDA
GO:0008152	Biological Process	metabolic process	IEA
GO:0031100	Biological Process	organ regeneration	IEP
GO:0033590	Biological Process	response to cobalamin	IEP
GO:0042493	Biological Process	response to drug	IEP
GO:0051384	Biological Process	response to glucocorticoid stimulus	IEP
GO:0009408	Biological Process	response to heat	IEP
GO:0001666	Biological Process	response to hypoxia	IEP
GO:0033591	Biological Process	response to L-ascorbic acid	IEP
GO:0010288	Biological Process	response to lead ion	IEP
GO:0032496	Biological Process	response to lipopolysaccharide	IEP
GO:0032026	Biological Process	response to magnesium ion	IEP
GO:0010165	Biological Process	response to X-ray	IEP
GO:0007283	Biological Process	spermatogenesis	IEP

Sequences :

MRALGAVVTLLLWGQLFAVELGNDATDIEDDSCPKPPEIANGYVEHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAPTLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGRMGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILNKHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN

Function :

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).