P06727
UniProt ID : P06727
NCBI Taxonomy : 9606
Protein names : Apolipoprotein A-IV
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Secreted;
Length : 396
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0042627Cellular ComponentchylomicronIDA
GO:0005829Cellular ComponentcytosolTAS
GO:0005769Cellular Componentearly endosomeTAS
GO:0005788Cellular Componentendoplasmic reticulum lumenTAS
GO:0034364Cellular Componenthigh-density lipoprotein particleIDA
GO:0034361Cellular Componentvery-low-density lipoprotein particleIDA
GO:0016209Molecullar Functionantioxidant activityIDA
GO:0017127Molecullar Functioncholesterol transporter activityIDA
GO:0005507Molecullar Functioncopper ion bindingIDA
GO:0031210Molecullar Functionphosphatidylcholine bindingIDA
GO:0060228Molecullar Functionphosphatidylcholine-sterol O-acyltransferase activator activityIDA
GO:0042803Molecullar Functionprotein homodimerization activityIDA
GO:0033344Biological Processcholesterol effluxIDA
GO:0042632Biological Processcholesterol homeostasisIDA
GO:0008203Biological Processcholesterol metabolic processIDA
GO:0034378Biological Processchylomicron assemblyTAS
GO:0034371Biological Processchylomicron remodelingIC
GO:0034375Biological Processhigh-density lipoprotein particle remodelingIC
GO:0042744Biological Processhydrogen peroxide catabolic processIDA
GO:0002227Biological Processinnate immune response in mucosaIDA
GO:0007159Biological Processleukocyte cell-cell adhesionIDA
GO:0042157Biological Processlipoprotein metabolic processTAS
GO:0044240Biological Processmulticellular organismal lipid catabolic processIDA
GO:0034445Biological Processnegative regulation of plasma lipoprotein particle oxidationIDA
GO:0046470Biological Processphosphatidylcholine metabolic processIDA
GO:0033700Biological Processphospholipid effluxIDA
GO:0007603Biological Processphototransduction, visible lightTAS
GO:0010873Biological Processpositive regulation of cholesterol esterificationIDA
GO:0045723Biological Processpositive regulation of fatty acid biosynthetic processIDA
GO:0051006Biological Processpositive regulation of lipoprotein lipase activityIDA
GO:0010898Biological Processpositive regulation of triglyceride catabolic processIDA
GO:0032374Biological Processregulation of cholesterol transportIDA
GO:0030300Biological Processregulation of intestinal cholesterol absorptionIEA
GO:0019430Biological Processremoval of superoxide radicalsIDA
GO:0006982Biological Processresponse to lipid hydroperoxideIDA
GO:0035634Biological Processresponse to stilbenoidIEA
GO:0001523Biological Processretinoid metabolic processTAS
GO:0043691Biological Processreverse cholesterol transportIDA
GO:0034372Biological Processvery-low-density lipoprotein particle remodelingIDA
SWISS-MODEL Repository :P06727
Sequences : MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
Function :May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.