P05067
UniProt ID : P05067
NCBI Taxonomy : 9606
Protein names : Amyloid beta A4 protein
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Membrane;Membrane;
Length : 770
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0045177Cellular Componentapical part of cellIEA
GO:0030424Cellular ComponentaxonISS
GO:0009986Cellular Componentcell surfaceIDA
GO:0035253Cellular Componentciliary rootletIEA
GO:0005905Cellular Componentcoated pitIEA
GO:0005829Cellular ComponentcytosolTAS
GO:0043198Cellular Componentdendritic shaftIDA
GO:0043197Cellular Componentdendritic spineIDA
GO:0005576Cellular Componentextracellular regionTAS
GO:0005794Cellular ComponentGolgi apparatusIDA
GO:0005887Cellular Componentintegral to plasma membraneTAS
GO:0031594Cellular Componentneuromuscular junctionIEA
GO:0048471Cellular Componentperinuclear region of cytoplasmIEA
GO:0031093Cellular Componentplatelet alpha granule lumenTAS
GO:0051233Cellular Componentspindle midzoneIEA
GO:0045202Cellular ComponentsynapseIDA
GO:0003677Molecullar FunctionDNA bindingISS
GO:0008201Molecullar Functionheparin bindingIEA
GO:0016504Molecullar Functionpeptidase activator activityIEA
GO:0004867Molecullar Functionserine-type endopeptidase inhibitor activityIDA
GO:0046914Molecullar Functiontransition metal ion bindingIEA
GO:0008344Biological Processadult locomotory behaviorISS
GO:0008088Biological Processaxon cargo transportISS
GO:0016199Biological Processaxon midline choice point recognitionISS
GO:0007155Biological Processcell adhesionIEA
GO:0006878Biological Processcellular copper ion homeostasisISS
GO:0008203Biological Processcholesterol metabolic processIEA
GO:0048669Biological Processcollateral sprouting in absence of injuryISS
GO:0016358Biological Processdendrite developmentISS
GO:0006897Biological ProcessendocytosisISS
GO:0030198Biological Processextracellular matrix organizationISS
GO:0030900Biological Processforebrain developmentIEA
GO:0000085Biological ProcessG2 phase of mitotic cell cycleISS
GO:0045087Biological Processinnate immune responseTAS
GO:0035235Biological Processionotropic glutamate receptor signaling pathwayISS
GO:0007617Biological Processmating behaviorISS
GO:0006378Biological ProcessmRNA polyadenylationISS
GO:0045665Biological Processnegative regulation of neuron differentiationIEA
GO:0050885Biological Processneuromuscular process controlling balanceIEA
GO:0051402Biological Processneuron apoptotic processIMP
GO:0016322Biological Processneuron remodelingISS
GO:0007219Biological ProcessNotch signaling pathwayIEA
GO:0035872Biological Processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0030168Biological Processplatelet activationTAS
GO:0002576Biological Processplatelet degranulationTAS
GO:0010971Biological Processpositive regulation of G2/M transition of mitotic cell cycleIEA
GO:0045931Biological Processpositive regulation of mitotic cell cycleISS
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoterIEA
GO:0006468Biological Processprotein phosphorylationISS
GO:0007176Biological Processregulation of epidermal growth factor-activated receptor activityISS
GO:0040014Biological Processregulation of multicellular organism growthISS
GO:0043393Biological Processregulation of protein bindingIEA
GO:0050803Biological Processregulation of synapse structure and activityISS
GO:0006417Biological Processregulation of translationISS
GO:0006979Biological Processresponse to oxidative stressIEA
GO:0051563Biological Processsmooth endoplasmic reticulum calcium ion homeostasisIEA
GO:0001967Biological Processsuckling behaviorIEA
GO:0051124Biological Processsynaptic growth at neuromuscular junctionIEA
GO:0008542Biological Processvisual learningISS
SWISS-MODEL Repository :P05067
Sequences : MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Function :Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.