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P02649

UniProt ID :

P02649

NCBI Taxonomy :

9606

Protein names :

Apolipoprotein E

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Secreted;

Length :

317

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0042627	Cellular Component	chylomicron	IDA
GO:0030425	Cellular Component	dendrite	NAS
GO:0005769	Cellular Component	early endosome	TAS
GO:0071682	Cellular Component	endocytic vesicle lumen	TAS
GO:0031232	Cellular Component	extrinsic to external side of plasma membrane	IEA
GO:0005794	Cellular Component	Golgi apparatus	IEA
GO:0034364	Cellular Component	high-density lipoprotein particle	IDA
GO:0034363	Cellular Component	intermediate-density lipoprotein particle	IDA
GO:0005770	Cellular Component	late endosome	IEA
GO:0034362	Cellular Component	low-density lipoprotein particle	IDA
GO:0043025	Cellular Component	neuronal cell body	NAS
GO:0005886	Cellular Component	plasma membrane	TAS
GO:0034361	Cellular Component	very-low-density lipoprotein particle	IDA
GO:0016209	Molecullar Function	antioxidant activity	IDA
GO:0001540	Molecullar Function	beta-amyloid binding	IDA
GO:0017127	Molecullar Function	cholesterol transporter activity	IEA
GO:0008201	Molecullar Function	heparin binding	IDA
GO:0046848	Molecullar Function	hydroxyapatite binding	IEA
GO:0005319	Molecullar Function	lipid transporter activity	IDA
GO:0071813	Molecullar Function	lipoprotein particle binding	IEA
GO:0050750	Molecullar Function	low-density lipoprotein particle receptor binding	IDA
GO:0046911	Molecullar Function	metal chelating activity	IDA
GO:0060228	Molecullar Function	phosphatidylcholine-sterol O-acyltransferase activator activity	IDA
GO:0005543	Molecullar Function	phospholipid binding	IDA
GO:0042803	Molecullar Function	protein homodimerization activity	IDA
GO:0070326	Molecullar Function	very-low-density lipoprotein particle receptor binding	IDA
GO:0007568	Biological Process	aging	IEA
GO:0048844	Biological Process	artery morphogenesis	IEA
GO:0008219	Biological Process	cell death	IEA
GO:0006874	Biological Process	cellular calcium ion homeostasis	IEA
GO:0071397	Biological Process	cellular response to cholesterol	IEA
GO:0071363	Biological Process	cellular response to growth factor stimulus	IEA
GO:0071347	Biological Process	cellular response to interleukin-1	IEA
GO:0019934	Biological Process	cGMP-mediated signaling	IDA
GO:0006707	Biological Process	cholesterol catabolic process	IEA
GO:0033344	Biological Process	cholesterol efflux	IDA
GO:0042632	Biological Process	cholesterol homeostasis	IDA
GO:0008203	Biological Process	cholesterol metabolic process	IDA
GO:0034382	Biological Process	chylomicron remnant clearance	IMP
GO:0007010	Biological Process	cytoskeleton organization	TAS
GO:0007186	Biological Process	G-protein coupled receptor signaling pathway	IDA
GO:0034380	Biological Process	high-density lipoprotein particle assembly	IDA
GO:0034384	Biological Process	high-density lipoprotein particle clearance	IDA
GO:0034375	Biological Process	high-density lipoprotein particle remodeling	IGI
GO:0046907	Biological Process	intracellular transport	TAS
GO:0042158	Biological Process	lipoprotein biosynthetic process	IEA
GO:0042159	Biological Process	lipoprotein catabolic process	IEA
GO:0042157	Biological Process	lipoprotein metabolic process	TAS
GO:0034374	Biological Process	low-density lipoprotein particle remodeling	IEA
GO:0051651	Biological Process	maintenance of location in cell	IEA
GO:0043537	Biological Process	negative regulation of blood vessel endothelial cell migration	IDA
GO:0045541	Biological Process	negative regulation of cholesterol biosynthetic process	IDA
GO:0001937	Biological Process	negative regulation of endothelial cell proliferation	IDA
GO:0050728	Biological Process	negative regulation of inflammatory response	IC
GO:0043407	Biological Process	negative regulation of MAP kinase activity	IDA
GO:0043524	Biological Process	negative regulation of neuron apoptotic process	IEA
GO:0010544	Biological Process	negative regulation of platelet activation	IDA
GO:0007263	Biological Process	nitric oxide mediated signal transduction	IDA
GO:0048709	Biological Process	oligodendrocyte differentiation	IEA
GO:0014012	Biological Process	peripheral nervous system axon regeneration	IEA
GO:0033700	Biological Process	phospholipid efflux	IDA
GO:0007603	Biological Process	phototransduction, visible light	TAS
GO:0045773	Biological Process	positive regulation of axon extension	IEA
GO:0030828	Biological Process	positive regulation of cGMP biosynthetic process	IDA
GO:0010875	Biological Process	positive regulation of cholesterol efflux	IDA
GO:0010873	Biological Process	positive regulation of cholesterol esterification	IDA
GO:0032805	Biological Process	positive regulation of low-density lipoprotein particle receptor catabolic process	IDA
GO:0051044	Biological Process	positive regulation of membrane protein ectodomain proteolysis	IDA
GO:0051000	Biological Process	positive regulation of nitric-oxide synthase activity	IDA
GO:0006898	Biological Process	receptor-mediated endocytosis	IDA
GO:0030516	Biological Process	regulation of axon extension	TAS
GO:0032489	Biological Process	regulation of Cdc42 protein signal transduction	IDA
GO:0010468	Biological Process	regulation of gene expression	IEA
GO:0048168	Biological Process	regulation of neuronal synaptic plasticity	TAS
GO:0002021	Biological Process	response to dietary excess	IEA
GO:0045471	Biological Process	response to ethanol	IEA
GO:0032868	Biological Process	response to insulin stimulus	IEA
GO:0000302	Biological Process	response to reactive oxygen species	NAS
GO:0032526	Biological Process	response to retinoic acid	IEA
GO:0001523	Biological Process	retinoid metabolic process	TAS
GO:0043691	Biological Process	reverse cholesterol transport	IDA
GO:0007271	Biological Process	synaptic transmission, cholinergic	TAS
GO:0006641	Biological Process	triglyceride metabolic process	IDA
GO:0042311	Biological Process	vasodilation	IEA
GO:0034447	Biological Process	very-low-density lipoprotein particle clearance	IDA
GO:0034372	Biological Process	very-low-density lipoprotein particle remodeling	IDA

SWISS-MODEL Repository :

P02649

Sequences :

MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

Function :

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.