P00441
UniProt ID : P00441
NCBI Taxonomy : 9606
Protein names : Superoxide dismutase [Cu-Zn]
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Cytoplasm;
Length : 154
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0031410Cellular Componentcytoplasmic vesicleIDA
GO:0005829Cellular ComponentcytosolIDA
GO:0032839Cellular Componentdendrite cytoplasmIDA
GO:0031012Cellular Componentextracellular matrixIDA
GO:0005615Cellular Componentextracellular spaceIDA
GO:0005759Cellular Componentmitochondrial matrixNAS
GO:0043025Cellular Componentneuronal cell bodyIDA
GO:0005634Cellular ComponentnucleusIDA
GO:0005777Cellular ComponentperoxisomeIDA
GO:0043234Cellular Componentprotein complexIDA
GO:0005507Molecullar Functioncopper ion bindingIDA
GO:0042803Molecullar Functionprotein homodimerization activityNAS
GO:0030346Molecullar Functionprotein phosphatase 2B bindingIDA
GO:0048365Molecullar FunctionRac GTPase bindingIDA
GO:0004784Molecullar Functionsuperoxide dismutase activityIDA
GO:0008270Molecullar Functionzinc ion bindingIDA
GO:0000187Biological Processactivation of MAPK activityISS
GO:0008089Biological Processanterograde axon cargo transportISS
GO:0006309Biological Processapoptotic DNA fragmentationISS
GO:0060088Biological Processauditory receptor cell stereocilium organizationISS
GO:0007569Biological Processcell agingIMP
GO:0006879Biological Processcellular iron ion homeostasisISS
GO:0006302Biological Processdouble-strand break repairISS
GO:0007566Biological Processembryo implantationISS
GO:0006749Biological Processglutathione metabolic processISS
GO:0060047Biological Processheart contractionIDA
GO:0050665Biological Processhydrogen peroxide biosynthetic processIDA
GO:0007626Biological Processlocomotory behaviorISS
GO:0046716Biological Processmuscle cell cellular homeostasisISS
GO:0002262Biological Processmyeloid cell homeostasisISS
GO:0045541Biological Processnegative regulation of cholesterol biosynthetic processIDA
GO:0043524Biological Processnegative regulation of neuron apoptotic processISS
GO:0060052Biological Processneurofilament cytoskeleton organizationISS
GO:0001541Biological Processovarian follicle developmentISS
GO:0032287Biological Processperipheral nervous system myelin maintenanceISS
GO:0001890Biological Processplacenta developmentNAS
GO:0030168Biological Processplatelet activationTAS
GO:0002576Biological Processplatelet degranulationTAS
GO:0043065Biological Processpositive regulation of apoptotic processIC
GO:0001819Biological Processpositive regulation of cytokine productionIDA
GO:1902177Biological Processpositive regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIMP
GO:0032930Biological Processpositive regulation of superoxide anion generationIDA
GO:0008217Biological Processregulation of blood pressureISS
GO:0051881Biological Processregulation of mitochondrial membrane potentialIMP
GO:0040014Biological Processregulation of multicellular organism growthISS
GO:0046620Biological Processregulation of organ growthNAS
GO:0032314Biological Processregulation of Rac GTPase activityIDA
GO:0033081Biological Processregulation of T cell differentiation in thymusNAS
GO:0060087Biological Processrelaxation of vascular smooth muscleISS
GO:0019430Biological Processremoval of superoxide radicalsISS
GO:0001975Biological Processresponse to amphetamineIEA
GO:0048678Biological Processresponse to axon injuryISS
GO:0046688Biological Processresponse to copper ionIEA
GO:0042493Biological Processresponse to drugISS
GO:0045471Biological Processresponse to ethanolISS
GO:0009408Biological Processresponse to heatISS
GO:0042542Biological Processresponse to hydrogen peroxideISS
GO:0031667Biological Processresponse to nutrient levelsIEA
GO:0001895Biological Processretina homeostasisISS
GO:0008090Biological Processretrograde axon cargo transportISS
GO:0007605Biological Processsensory perception of soundISS
GO:0007283Biological ProcessspermatogenesisISS
GO:0042554Biological Processsuperoxide anion generationIEA
GO:0048538Biological Processthymus developmentNAS
Catalytic activity :2 superoxide + 2 H+ = O2 + H2O2.
SWISS-MODEL Repository :P00441
Sequences : MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Function :Destroys radicals which are normally produced within the cells and which are toxic to biological systems.