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O75444

UniProt ID :

O75444

NCBI Taxonomy :

9606

Protein names :

Transcription factor Maf

Organism :

Homo sapiens

Taxonomy :

Eukaryota

Subcellular locations :

Nucleus;

Length :

373

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0000785	Cellular Component	chromatin	TAS
GO:0005737	Cellular Component	cytoplasm	IEA
GO:0005634	Cellular Component	nucleus	IEA
GO:0043565	Molecullar Function	sequence-specific DNA binding	IEA
GO:0003700	Molecullar Function	sequence-specific DNA binding transcription factor activity	IEA
GO:0048468	Biological Process	cell development	IEA
GO:0001816	Biological Process	cytokine production	IEA
GO:0048839	Biological Process	inner ear development	IEA
GO:0070306	Biological Process	lens fiber cell differentiation	IEA
GO:0000122	Biological Process	negative regulation of transcription from RNA polymerase II promoter	IEA
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0032330	Biological Process	regulation of chondrocyte differentiation	IEA
GO:0006366	Biological Process	transcription from RNA polymerase II promoter	TAS

SWISS-MODEL Repository :

O75444

Sequences :

MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM

Function :

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.