UniProt ID : O75444
NCBI Taxonomy : 9606
Protein names : Transcription factor Maf
Organism : Homo sapiens
Taxonomy : Eukaryota
Subcellular locations :Nucleus;
Length : 373
Gene Ontology :
GO IDOntologyDefinitionEvidence
GO:0000785Cellular ComponentchromatinTAS
GO:0005737Cellular ComponentcytoplasmIEA
GO:0005634Cellular ComponentnucleusIEA
GO:0043565Molecullar Functionsequence-specific DNA bindingIEA
GO:0003700Molecullar Functionsequence-specific DNA binding transcription factor activityIEA
GO:0048468Biological Processcell developmentIEA
GO:0001816Biological Processcytokine productionIEA
GO:0048839Biological Processinner ear developmentIEA
GO:0070306Biological Processlens fiber cell differentiationIEA
GO:0000122Biological Processnegative regulation of transcription from RNA polymerase II promoterIEA
GO:0045944Biological Processpositive regulation of transcription from RNA polymerase II promoterIEA
GO:0032330Biological Processregulation of chondrocyte differentiationIEA
GO:0006366Biological Processtranscription from RNA polymerase II promoterTAS
SWISS-MODEL Repository :O75444
Function :Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.