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O55234

UniProt ID :

O55234

NCBI Taxonomy :

10090

Protein names :

Proteasome subunit beta type-5

Organism :

Mus musculus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

264

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005829	Cellular Component	cytosol	TAS
GO:0005634	Cellular Component	nucleus	IEA
GO:0005839	Cellular Component	proteasome core complex	IDA
GO:0008233	Molecullar Function	peptidase activity	IDA
GO:0004298	Molecullar Function	threonine-type endopeptidase activity	IEA
GO:0043161	Biological Process	proteasomal ubiquitin-dependent protein catabolic process	IDA
GO:0006979	Biological Process	response to oxidative stress	IDA

Catalytic activity :

Cleavage of peptide bonds with very broad specificity.

SWISS-MODEL Repository :

O55234

Sequences :

MALASVLQRPMPVNQHGFFGLGGGADLLDLGPGSPGDGLSLAAPSWGVPEEPRIEMLHGTTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSSVSVP

Function :

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib (By similarity). Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway.