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O54968

UniProt ID :

O54968

NCBI Taxonomy :

10116

Protein names :

Nuclear factor erythroid 2-related factor 2

Organism :

Rattus norvegicus

Taxonomy :

Eukaryota

Subcellular locations :

Cytoplasm;Nucleus;

Length :

604

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005813	Cellular Component	centrosome	IEA
GO:0000785	Cellular Component	chromatin	IEA
GO:0005737	Cellular Component	cytoplasm	IDA
GO:0005829	Cellular Component	cytosol	IEA
GO:0005634	Cellular Component	nucleus	IDA
GO:0005886	Cellular Component	plasma membrane	IEA
GO:0043565	Molecullar Function	sequence-specific DNA binding	IDA
GO:0003700	Molecullar Function	sequence-specific DNA binding transcription factor activity	IEA
GO:0070301	Biological Process	cellular response to hydrogen peroxide	IEA
GO:0071499	Biological Process	cellular response to laminar fluid shear stress	IEA
GO:0071356	Biological Process	cellular response to tumor necrosis factor	IEA
GO:0030968	Biological Process	endoplasmic reticulum unfolded protein response	IEA
GO:0060548	Biological Process	negative regulation of cell death	IMP
GO:2000352	Biological Process	negative regulation of endothelial cell apoptotic process	IEA
GO:1902176	Biological Process	negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress	IEA
GO:0030194	Biological Process	positive regulation of blood coagulation	IEA
GO:2000379	Biological Process	positive regulation of reactive oxygen species metabolic process	IEA
GO:0036003	Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	IEA
GO:0043161	Biological Process	proteasomal ubiquitin-dependent protein catabolic process	ISS
GO:0010499	Biological Process	proteasomal ubiquitin-independent protein catabolic process	ISS
GO:0016567	Biological Process	protein ubiquitination	ISS
GO:0045995	Biological Process	regulation of embryonic development	IEA
GO:2000121	Biological Process	regulation of removal of superoxide radicals	IEA
GO:0006351	Biological Process	transcription, DNA-dependent	IEA

Sequences :

MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGSVSYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLALDIPSHVESSVFTTPDQAQSLDSSLETAMTDLSSIQQDMEQVWQELFSIPELQCLNTENKQQAETTTVPSPEATLTEMDSNYHFYSSIPSLEKEVDSCSPHFLHGFEDSFSSILSTDDASQLNSLDSNPTLNTDFGDEFYSAFLAEPSGGGSMPSSAAISQSLSELLGGPIEGCDLSLCKAFNQKHTEGTVEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPAQGHSAAVHESQCENTTKKEVPVSPGHQKVPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN

Function :

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity).